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[1] Schwedhelm E et al

When GLP-1 receptors activate on these cells, they can dampen the production of pro-inflammatory molecules, potentially reducing systemic inflammation throughout the body

Eduardo Grunvald, M.D., FACP, Medical Director of the University of California San Diego Center for Advanced Weight Management, though he points out that the benefits of treating obesity outweigh that risk

However, their clinical utility remains limited due to heterogeneous metabolic effects and adverse outcomes, such as elevated alanine aminotransferase (ALT), increased low-density lipoprotein cholesterol (LDL-C), and weight gain ( 5.4 Species and region-specific glucagon actions: a translational challenge One major obstacle in glucagon research is the species-specific differences in glucagon receptor expression and function, which make it difficult to apply findings from animal studies to humans