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Arterial blood gas (ABG) performed on admission revealed severe metabolic acidosis with normal lactate level and anion gap of 32 (pH 6.9
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The levels of TSH, FT3 and FT4 in Pem037 had normalised, and TRAb was no longer detected, at 91 days after the development of hyperthyroidism without requiring medications
Simplified pathway: afamelanotide activates MC1R intracellular signalling increases melanogenic enzymes become more active eumelanin production rises
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