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[PMC free article: PMC2795667] [PubMed: 19890023] 68

States directly that the GLP-2 receptor is localized to intestinal cell types that do not include the proliferating crypt cells, and that growth is mediated indirectly via IGF-1, IGF-2, KGF, VIP and nitric oxide released from subepithelial myofibroblasts and enteric neurons

In its early days, AUC was intensively used by Svedbergs team for evaluation of the molecular mass of proteins, such as hemoglobin (Svedberg and Fhraeus, 1926), egg albumin (Svedberg and Nichols, 1926), phycoerythrin and phycocyan (Svedberg and Lewis, 1928), serum albumin and of serum globulin (Svedberg and Sjgren, 1928), hemocyanin (Svedberg and Chirnoaga, 1928

The peptide is cleared rapidly, which is one explanation for why its effects appear difficult to reproduce and why protocols tie dosing closely to the observation window