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Berberine should not be described as a GLP-1 'activator' in the medicinal sense, as any effects on GLP-1 pathways appear to be indirect and considerably less potent than pharmaceutical GLP-1 therapies

The following era (1985 to present) of molecular genetics, recombinant technology and the generation of genetically modified biological systems has expanded our understanding of the regulation and role of the GHIGF axis

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