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Bodyweight plays a role, as heavier individuals tend to run the higher end, but 250 mcg twice daily is where the majority of users land and where Id start

This creates a metabolic environment where weight loss becomes exceptionally difficult and fat storage, particularly visceral fat around the abdomen, becomes the default

For leaky gut and barrier integrity, BPC-157 stands out

When to seek urgent medical advice : Sudden worsening of joint pain, swelling, or stiffness Signs of infection (fever, malaise, localised warmth) Severe abdominal pain (potential pancreatitis if on GLP-1 therapy) Unexplained persistent nausea or vomiting Any concerning new symptoms after starting any new medication According to NICE Quality Standard 33, if you have suspected persistent synovitis, you should be referred to rheumatology within 3 working days and assessed within 3 weeks