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Rather than relying on traditional differential gene expression analysis, GSVA would provide a more holistic approach by considering the collective expression behaviors of genes within predefined gene sets or pathways

10.1016/j.jpeds.2006.09.042 J Pediatr

In 2021, approximately 537 million adults worldwide were diagnosed with diabetes, and this number is projected to rise to 783 million by 2045 ( Beyond its metabolic consequences, cigarette smoking is causally associated with chronic obstructive pulmonary disease, interstitial lung disease ( Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the treatment of T2DM due to their glucose-lowering efficacy and beneficial effects on body weight ( A recent large-scale real-world observational study using target trial emulation reported an association between semaglutide use and a reduced risk of tobacco use disorder in patients with T2DM ( Therefore, this randomized controlled trial aims to investigate the effects of GLP-RA on nicotine dependence and smoking-related outcomes in patients with T2DM, and to explore potential neural mechanisms using functional magnetic resonance imaging (fMRI)

Consistency and patience are important through the early phase