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However, current evidence predominantly derives from animal models and in vitro systems, underscoring the need for large-scale, multicenter clinical trials in high-altitude populations to validate drug-microbiome interactions

Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S,

A systems-based approach and customized drug testing techniques may be required to gain a deeper understanding of the underlying mechanisms and causes ( Integration of pharmacogenomics, metabolomics and microbiomics: Path to personalized metformin therapy Until recently, personalized medicine in T2D has predominantly focused on variation in DNA sequence