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The paradigm for treating people with obesity has often been to recommend lifestyle changes, and then if they develop diabetes or another metabolic condition, to treat them with metformin, insulin, or GLP-1 drugs, says study senior and corresponding author Andrew Stokes, associate professor of global health

Tirzepatide (highest doses in SURMOUNT-1) produced average losses near or above 20%, depending on dose, with clear dose-response effects in pivotal trials

After adding the liquid, gently swirl or roll it between your hands

This allows semaglutide to be administered once weekly for sustained therapeutic effects, whereas natural GLP-1 functions only as a brief meal-related signal