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Medicine has learned hard lessons from past cure-alls that went awry

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Phase 3 TRIUMPH-4 trial The most recent Phase 3 results, announced in December 2025, tested retatrutide in people with obesity and knee osteoarthritis

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People who took GLP-1 drugs had lower risk of all kinds of drug and alcohol addiction A large epidemiological study of more than 600,000 veterans with diabetes suggests GLP-1 weight-loss medications may reduce drug- and alcohol-related overdoses and deaths PharmaceuticalsFebruary 26, 2026 Head-to-head trial pitting Eli Lillys oral GLP-1 against oral semaglutide underscores efficacy of weight-loss pills A new trial found that Eli Lillys GLP-1 pill resulted in greater reductions in blood sugar levels and weight than oral semaglutide did, but fewer people stayed on it Lauren J

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