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Chronic intermittent hypoxia predisposes to liver injury

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Overcoming these barriers will require precision process design, pilot-scale validation, and integrative system planning to harmonize energy neutrality with treatment efficacy

Lancet Oncol 16(6):619629 Demetri GD et al (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial