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The aim is to reduce progression and to reduce the need for future knee replacement or other knee surgeries

The medication's central nervous system effects may also play a role, though this mechanism is hypothetical

Abstract Identification of the mechanisms by which drugs of abuse cause neuronal dysfunction is essential for understanding the biological bases of their acute and long-lasting effects in the brain

Additional study confirmed LONP1 downregulation in renal tissues from patients with MCD and revealed that inactivation of ERK1/2 induced by TRPC6 knockout ameliorates podocyte injury in MCD by increasing LONP1 expression [122]