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Variants of this gene are also involved in medication resistance to antiviral and anticancer drugs.[ref] The wet earwax allele was also associated with a higher risk of breast cancer in Japanese women but not in women of European descent.[ref][ref][ref] In Japanese men, carrying the allele associated with wet earwax is linked with an increased risk of hidradenitis suppurativa .[ref] Hidradenitis suppurativa is a painful skin condition causing pus-filled lumps under the skin, usually in the underarms, buttocks, or groin areas
The plasma was prepared by centrifugation at 800 g for 10 min at 4 C
Summary of preclinical research observations
(2007) 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes
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