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A crucial role of lactate accumulation in cancer cells has been demonstrated regarding its ability to induce expression of anti-inflammatory and proangiogenic genes, together with the modification of histones through a process called lactylation, where a lactyl-CoA is added to lysine residues present in the tails of histones [33]
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To investigate the effects of uridine supplementation on the in vivo maturation of oocytes in aged mice, oocytes were harvested from each group after superovulation, and systematically assessed for quantity and morphology (Fig
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