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Endogenous morphine, biosynthetically derived from dopamine, functions as a homeostatic modulator that stabilizes neuronal excitability via -opioid receptor signaling, with downstream coupling to nitric oxide production

Tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for obesity, introduces an additional mechanism by activating both GLP-1 and GIP receptors , which may amplify metabolic benefits