The authors acknowledge that their interpretation is limited by inadequate knowledge of the function of the ALA alleles of GPx-1 gene
447,448,449,450 Upregulated autophagy in macrophages enhances the production of pro-inflammatory cytokines such as IL-6 and TNF-, while autophagy deficiency promotes exaggerated inflammasome activation, as demonstrated by ATG16L1 ablation increasing IL-1 and IL-18 secretion
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Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al
