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The main phylum categories include Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Verrucomycetes ( The gut microbiota undergoes corresponding changes owing to factors such as host genetics, diet, and environment, which can promote the growth of pathogenic bacteria (Sun et al., 2019),multiple sclerosis (MS) ( Prevotella in the feces of RA patients is higher ( Faecalibacterium and Bacteroides are reduced ( Prevotella and Pseudomonas typically shows a decrease in the feces of patients with MS ( Akkermansia muciniphila typically increase (Ventura et al., 2019)