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By contrast, knockout mice for ANGPTL6 show an increased incidence of obesity, insulin resistance, and increased fat content in peripheral organs (especially the liver and skeletal muscle) (42)

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J Exerc Physiol Online 2000;3:2636

[30] A 2000 study to determine increases of eumelanin expression in seven, "normal volunteers" administered [Nle 4 , D-Phe 7 ]-MSH concluded that, "the tanning induced by Melanotan in the face and forearm is associated with a significant increase in the eumelanin content of the human skin." [31] Three 2004 Phase I clinical trials sought to establish the safety of [Nle 4 , D-Phe 7 ]-MSH therapy combined with UV-B light or sunlight exposure