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In addition, NIX is bound to LC3 through GABA type A receptor-associated protein (GABARAP) for initiation in NIX-dependent mitophagy

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10.1016/j.actbio.2016.08.010 Adv

This shift is partly due to decreased corticosteroid-binding globulin and diminished hepatic breakdown, which may heighten sensitivity to corticosteroids and contribute to features resembling hypercortisolism, including hypertension, hyperglycemia, and muscle wasting[54]