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Subsequently, using regulated disruption of these conditional alleles, mouse cells homozygous null for either allele have been shown to replicate vigorously (Mandal et al., 2010

However, the exact causation between the two, and thus the wider impact of the disorder on brain health, has not yet been fully established

We hypothesized that characterization of patients' metabolic profiles, utilizing high resolution 1H-nuclear magnetic resonance (NMR) may predict response to therapy prior to treatment