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GIP receptor agonism improves adipose tissue insulin sensitivity through a pathway distinct from the GLP-1 mechanism, meaning tirzepatide may interrupt the insulin-androgen cascade at multiple biological nodes simultaneously
Participants receiving cagrilintide were roughly 28 times more likely to experience some form of injection site reaction compared to those receiving placebo injections
This symptom is usually mild to moderate and tends to improve over time as the body adjusts to the medication
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