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Phase 1 (Pre-test screening and preparation): includes patient selection for suspected asthma despite normal spirometry (1.1), identification of absolute contraindications such as severely reduced FEV ( 0.4 for reliable effect

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Topical serums work at the skin surface and in the uppermost layers of the dermis, which means they address pigmentation locally rather than systemically

Toxicol Appl Pharmacol 330:7483 Funes HA, Apostolova N, Alegre F, Blas-Garcia A, Alvarez A, Marti-Cabrera M, Esplugues JV (2014) Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of Efavirenz