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In contrast, a dysbiotic microbial configuration characterized by reduced BSH functional potential may contribute to a less efficient microbial transformation of bile acids, potentially influencing the composition of the host bile acid pool and its downstream signaling through FXR and TGR5 pathways

Tirzepatide has an obviously lower affinity with GIPR than GIP does (pIC 50 : 6.70 vs 7.87), and its cAMP activity is approximately equal to that of GIP

iso-osmolar contrast agents differ in their ability to trigger ferroptosis, or if dose-dependent thresholds exist, is unclear

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