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During the first 24 weeks, you may experience: Nausea (the most frequently reported side effect, affecting 20-40% of patients initially, varying by product and dose according to SmPC data) [20] [17] Reduced appetite or early satiety Occasional vomiting Mild abdominal discomfort or bloating Changes in bowel habits, including constipation or diarrhoea These effects typically diminish as your body adjusts to the medication, usually within 48 weeks