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Antioxid (Basel) 12(8):1626

Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78

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(ii) herpesvirus positive individuals have lower activity of two antioxidant enzymes (GPX and SOD) than negative individuals when costs of antioxidant upregulation are high