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Unlike native -MSH, which has a very short plasma half-life due to rapid enzymatic degradation, MT-1 incorporates a linear sequence modification that significantly extends its stability in biological matrices while preserving high-affinity binding at melanocortin receptors primarily MC1R, the receptor responsible for eumelanin synthesis in melanocytes

Wing JJ, Levine DA, Ramamurthy A, Reider C

The loss of germline is proposed to induce an unknown longevity signal in the somatic gonad (Kenyon, 2010)

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