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In in vitro studies, exposing mature human adipocytes to Cd concentrations led to the altered expression of genes involved in trace element homeostasis and heavy metal detoxification

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However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]