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Compared to acute patients, we noted 495 metabolites were significantly reduced but 167 metabolites were elevated in the plasma of LC patients ( Figure 2I )

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Moreover, several clinical studies show that glycemia improves when doses are increased but with unacceptable rates of gastrointestinal adverse events 16,17,18 , suggesting that maximum benefits from GLP-1R agonism are in fact not realized with current treatments

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