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These results suggest that SYNCRIP regulates ferroptosis indirectly through the SIRT1/NRF2/xCT axis rather than by directly modulating GPX4

Adult-onset ornithine transcarbamylase (OTC) deficiency unmasked by the Atkins diet

indicated that canagliflozin could attenuate lipotoxicity and inflammatory injury in cardiomyocytes and protected diabetic mouse hearts via inhibiting the mTOR/hypoxia-inducible factor-1 (HIF-1) pathway [109]