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The lungs have a relatively high concentration of ascorbic acid in both intracellular and extracellular compartments in order to protect against inhaled pathogens and pollutants and the constant challenge caused by high oxygen levels [250]

Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice

Therefore, Met utilization may alter the DNA and histones methylation level, influencing the overall abundance of mRNA and proteins, and, consequently, the upcoming phenotype