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GLP-1RA exerts its glucose lowering effect by stimulating GLP-1 receptors, which not only has significant glucose-lowering efficacy, but also has the advantage of low incidence of hypoglycemia

For instance, liraglutide has been shown to enhance intracellular calcium levels in aortic endothelial cells, activating the CaMKK/AMPK axis to phosphorylate eNOS and CREB

Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells

Bubble plot representing pathways enriched for DEGs in ( a ) Gipr Syn / vehicle-treated and Gipr fl/fl mGIPR-Ab/P1-treated mice, and ( c ) Glp1r Wnt1 / vehicle-treated and Glp1r fl/fl mGIPR-Ab/P1-treated mice