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For comparative SAR studies: identical experimental conditions across MT-1, MT-II, and PT-141 treatment groups are essential for valid potency ratio determinations

| L-Tyrosine is a non-essential amino acid that plays a critical role in the production of several important neurotransmitters, including dopamine, norepinephrine, and epinephrine

Accordingly, studies using psychophysical testing, patient-reported food pleasure, cue-reactivity paradigms, and adverse-event reporting should not be interpreted as equivalent evidence for the same biological construct (Table 1)