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It is spread from person to person via female biting blackflies of the genus Simulium, and humans are the only known definitive host

It is a once-daily tablet taken on an empty stomach, prescribed only after clinical assessment against BMI-based eligibility and used alongside a reduced-calorie diet and increased physical activity

[DOI] [PMC free article] [PubMed] [Google Scholar] Dwarakanath S

The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]