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The discrepancy in the reports of p53 expression in keloids 5,26,27 suggests that the regulatory functions of p53 in keloid fibroblasts depends on activities rather than expression levels of p53

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Glossary ICD International Classification of Disease WHO World Health Organization MDD Major Depressive disorder SSRIs selective serotonin reuptake inhibitors SNRIs Serotonin-norepinephrine reuptake inhibitors TCA Tricyclic antidepressants MAOIs Monoamine oxidase inhibitors NMDA N-methyl-D-aspartate MDA malondialdehyde NO Nitric Oxide CNS Central Nervous System BDNF Brain-derived neurotrophic factors Author Contributions SC conceived the topic of the review