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These properties provide the potential for GLP-1 936 amide to behave as an agonist at low concentrations of intact GLP-1 but as an antagonist at higher concentrations when GLP-1R occupancy by GLP-1 936 amide would provide low efficacy signaling and inhibit GLP-1 736 amide binding

The absence of a clear testing standard means that outcomes can still vary depending on how impairment is defined and enforced in practice

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PMID: 31679083