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Tirzepatide, by contrast, activates GLP-1 and GIP receptors in the gut and brain, modulating appetite, glucose homeostasis, and gastrointestinal motility

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Optimal results require: Adherence to a reduced-calorie diet Regular physical activity (150+ minutes weekly of moderate intensity) Behavioural support and lifestyle modification Ongoing medical supervision Weight regain commonly occurs following medication discontinuation, highlighting the chronic nature of obesity management

After overcoming the initial nausea, Kirkley said she has experienced unexpected benefits linked to the class of weight-loss and diabetes drugs known as GLP-1s, sold under the brand names Ozempic, Wegovy, Mounjaro and Zepbound