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[DOI] [PubMed] [Google Scholar] 103.Pinto LC, Falcetta MR, Rados DV, Leitao CB, Gross JL

The connection between these medications and dental problems is still being figured out by researchers, but enough people are reporting issues that its worth taking action

There is accumulating evidence for numerous additional mechanisms of action separate from SGLT2 inhibition that appear to underlie the ability of gliflozins to produce additional effects associated with favorable outcomes, such as in the reduction of mortality and CV events in patients with heart failure

33,34 In this regard, glucagon-like peptide-1 (GLP-1) is one of the incretins with a pivotal role in many aspects of glucose regulation in the gutbrain axis because its receptor, the GLP-1 receptor (GLP-1R), is expressed not only in the pancreas but also widely in the periphery (such as in the lung, stomach, intestine, kidney, and heart) as well as most regions of the brain