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Documented Safety Concerns and Medical Contraindications Beyond GI side effects, GLP-1 drugs carry black-box warnings for medullary thyroid carcinoma risk (in animal models) and contraindications in personal or family history of thyroid cancer

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Aroda, M.D., from Brigham and Women's Hospital in Boston, and colleagues randomly assigned adults with type 2 diabetes inadequately controlled with diet and exercise to receive once-weekly subcutaneous cagrilintide 2.4 mg plus semaglutide 2.4 mg, cagrilintide 1.0 mg plus semaglutide 1.0 mg, or placebo for 40 weeks (62, 63, and 64 participants, respectively)

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