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When hemoglobin is oxidized, it will precipitate as Heinz bodies

ROS are involved in various physiological or pathological processes, such as metabolism, inflammation, neurogeneration and carcinogenesis [37,38,39,40]

At high concentrations, NO can react with superoxide to form peroxynitrite (ONOO ), a potent oxidant that depletes GSH and initiates lipid peroxidation, thereby driving ferroptosis