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This genetic clarity helps patients and providers select tirzepatide or semaglutide with confidence, rather than relying on trial-and-error dose adjustments

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It is FDA-approved for short-term use only (up to 12 weeks) Many doctors limit prescriptions to 3 months at a time Some physicians may prescribe it for longer periods "off-label" if they believe the benefits outweigh the risks The short-term limitation comes from a lack of long-term clinical trials and historical concerns about stimulant effects on the heart

This secondary analysis aimed to demonstrate the broader benefits of semaglutide use by determining both the NNT for semaglutide in terms of the primary CV composite of the SELECT trial and NNTs that capture additional clinically and payer-relevant outcomes reported as part of the secondary efficacy endpoints [21]