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Among inflammatory cytokines, IL-1 (Interleukin-1) is one of the most extensively studied in OA.Exposure of chondrocytes to IL1 results in pronounced upregulation of matrix metalloproteinasesparticularly MMP1, MMP3, and MMP13which catalyze the degradation of collagen and proteoglycans within the cartilage extracellular matrix, ultimately compromising its structural integrity