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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

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Mechanistic Insights in Human Models: Utilization of human-derived cardiac organoids, induced pluripotent stem cells (iPSCs), and organ-on-a-chip platforms can bridge the gap between animal studies and human relevance