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The Clinical Disease Activity Index (CDAI) : The CDAI is a quantitative composite measure used to assess disease activity and facilitate the timely adjustment of treatment regimens in patients with rheumatoid arthritis

reported that, different from in vitro assay, as l-cysteine is present in micromolar concentrations in the intracellular environment, the activity of -glutamyl phosphate reductase (GPR) encoded by PRO2 in eukaryotes or proA in prokaryotes must be shut off to allow -GC formation from -glutamyl phosphate [12]

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(117) confirmed that IS severely accumulates in patients with end-stage renal disease (ESRD), accompanied by significant expansion of indole-producing bacteria and upregulation of bacterial tryptophan metabolic pathways