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To better understand the degradation of peptide-antibody fusion, the same GLP-1 analogue fused to an isotype control antibody was administered to rats and the fusion protein was recovered and analysed by mass spectrometry seven days post-dose

20 FaillieJ.-L.BabaiS.CrpinS.BresV.LarocheM.-L.Le LouetH.et al (2014)

Many patients fear needles or find injections burdensome

Interestingly, wild-type mice had lower levels of IL-10 in the brain, whereas DPP4 mice had higher levels, suggesting a potential role of DPP4 in modulating neuroimmune responses during colitis onset