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By mimicking these hormones, semaglutide and tirzepatide slow gastric emptying (the speed at which food leaves the stomach)

the KYDN neurons and then GnRH-secreting neurons) (25), the positive improvement of the metabolic impairment is probably not the only one needed to re-activate a normal reproductive profile, given that no significant changes in plasma LH concentrations were observed during the 6 months of treatment

Dickinson, D.A., et al., Cytoprotection against oxidative stress and the regulation of glutathione synthesis

If somatotrophs are damaged or pituitary blood flow is poor, peptide responsiveness declines