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Through leave-one-out sensitivity testing, we confirmed that our findings were stable and not driven by any single study

Celebrity praise for these medications helps fuel public interest

dose-dependent response across 3, 6, and 9 mg arms Phase 3 T2D : HbA1c reductions up to 2.15% versus placebo in Chinese population trials Phase 1b/2 data : Earlier dose-finding studies establishing the efficacy and tolerability profile Global development : Ongoing clinical trials outside China, but no FDA approval or submission as of early 2026 Limitation : Primary clinical data from Chinese population

2 Pathophysiological basis: coupling of metabolic imbalance and reproductive axis 2.1 Heterogeneous phenotypes and neuroendocrine characteristics of PCOS Polycystic Ovary Syndrome is a clinically heterogeneous syndrome, and diagnosis remains syndromic: clinicians identify combinations of hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology (PCOM), while excluding disorders with similar presentations (49)