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The GH-stimulating activity was essentially a discovery

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.la Paz S.M.-D., Garcia-Gimenez M.D., Quilez A.M., De la Puerta R., Fernandez-Arche A

Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

Table 1 depicts basic information about AERs for anakinra and canakinumab