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Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering

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This means that during postnatal development in diseased retinas, greater excretion of GSSG, into extracellular space where it get hydrolyzed, could lead to an increase in the [GSH]/[GSSG] ratio