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It mainly includes increased concentrations of total cholesterol and/or triacylglycerol, as well as decreased concentrations of high-density lipoprotein cholesterol, which is one of the independent risk factors for cardiovascular and cerebrovascular diseases

The clearance (L/hr) of APAP increased from 2.02 L/hr at 1 month of age to 4.09 L/hr at 1 year of age to 14.27 L/hr at 16 years of age (based on our own analyses on the published mean values with a Spearman correlation, there is a significant correlation between age and APAP clearance, p G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure

With oral doses of 3 - 6 mg/kg no ataxia or death was observed

Sci Rep 4 , 4272 (2014)