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A similar magnitude of change was also observed for plasma ornithine concentration (9.5 3.1 M vs

Mode 1 primarily generates ribose 5-phosphate by conversion of glucose 6-phosphate into fructose 6-phosphate and glyceraldehyde 3-phosphate, which generate ribose 5-phosphate through reversal of transaldolase and transketolase reactions in the nonoxidative stage of PPP

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In a type 1 diabetic Akita mouse model, which was used as a nonobese insulin-dependent model of spontaneous type 1 diabetes, empagliflozin treatment attenuated diabetes-induced rise in renal expression of markers of kidney growth by reducing the cyclin-dependent kinase inhibitors p27 and p21, which were over-expressed in early diabetic kidneys (152)