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The metformin intervention also plays a role in glycerol-3-phosphate dehydrogenase and selectively inhibits the substrate (glycerol and lactate) involved in hepatic gluconeogenesis (Lamoia and Shulman, 2021)

The results revealed that it significantly increased the levels of Scr and BUN, suppressed the expression of fibronectin and -SMA, increased PTEN, and decreased p-Akt, which correlated with the downregulation of the enhancer of zeste homolog-2 (EZH2) and histone H3 lysine 27 trimethylation (H3K27me3) (Lin et al., 2023)

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